Accutane (isotretinoin) can be used for some cases of severe nodular acne that did not respond to other treatments attempted. You will need to visit your doctor regularly for your progress to be checked. Your health care provider will also make sure you are not pregnant - you will need to have negative pregnancy tests to get a refill. This has to do with the fact Accutane can be exceptionally harmful to an unborn baby if taken by a pregnant woman. An overdose of Accutane must be reported to your local emergency center. The following symptoms are possible: loss of coordination, flushing, dizziness, headache, vomiting, chapped lips, and stomach pain. Make sure you always take as much of Accutane as recommended. Tell your doctor if you get any side effects that do not go away or seem serious. The following side effects are considered serious enough to report: unusual thirst, dark colored urine, vision problems, painful dryness of the eyes, rash, frequent urination, difficulty hearing, yellowing of the skin or eyes, worsening heartburn, muscle weakness, joint or muscle pain, pounding heartbeat, rectal bleeding, diarrhea, and fever, although there may also be some other ones.